Plasma

Plasma Frozen within 24 hours after phlebotomy (PF24RT24) is prepared from apheresis collections. The product is held at room temperature for up to 24 hours after collection, then frozen at ≤–18°C. The anticoagulant solution and the component volume are on the label.

This plasma component is a source of non-labile plasma proteins. Levels of plasma proteins such as Factors II, VII, IX, X, and XI, fibrinogen, ADAMTS13, and albumin are similar to FFP.

Levels of Factor V, Factor VIII, and Protein S are reduced, and levels of other labile plasma proteins are variable compared with fresh frozen plasma (FFP).

Indications:

• Active bleeding or risk of bleeding due to deficiency of multiple coagulation factors.
• Urgent reversal of warfarin when a patient cannot wait for Vitamin K to take effect.
  
• Massive transfusion.
• Bleeding or prophylaxis of bleeding for a known single coagulation factor deficiency for which no concentrate is available.
• Plasma exchange, e.g., Thrombotic Thrombocytopenic Purpura (TTP).
  

Plasma Frozen within 24 hours (PF24) is prepared from whole blood. The product is frozen within 24 hours after collection at ≤–18°C. The anticoagulant solution and component volume are on the label.

This plasma component is a source of non-labile plasma proteins. Levels of plasma proteins such as Factors II, VII, IX, X, and XI, fibrinogen, ADAMTS13, and albumin are similar to FFP.

Levels of Factor V, Factor VIII, and Protein S are reduced and levels of other labile plasma proteins are variable compared with fresh frozen plasma (FFP).

Indications:

• Active bleeding or risk of bleeding due to deficiency of multiple coagulation factors.
  
• Urgent reversal of warfarin when a patient cannot wait for Vitamin K to take effect.
  
• Massive transfusion.
• Bleeding or prophylaxis of bleeding for a known single coagulation factor deficiency for which no concentrate is available.
• Plasma exchange, e.g., Thrombotic Thrombocytopenic Purpura (TTP).
  

Liquid Plasma is plasma that is never frozen; it is stored refrigerated at 1-6°C. The product provides immediate access in emergent situations (e.g., trauma). Irradiated Liquid Plasma is also available.

Indication:

• The only indication for Liquid Plasma is for the initial treatment of patients requiring massive transfusion because of life-threatening trauma or hemorrhage.

Fresh Frozen Plasma (FFP) is prepared from whole blood and is provided exclusively for neonatal and pediatric transfusions. FFP is a 3-bag divided set from single donation unit. Frozen at ≤–18°C or colder within 8 hours, volumes and anticoagulant solution are indicated on the label. Shelf life is one (1) year.

This plasma component contains plasma proteins including all coagulation factors. FFP contains normal levels of the labile coagulation Factors V and VIII.

Indications:

• Active bleeding or risk of bleeding due to deficiency of multiple coagulation factors.
• Urgent reversal of warfarin when a patient cannot wait for Vitamin K to take effect.
  
• Massive transfusion.
• Bleeding or prophylaxis of bleeding for a known single coagulation factor deficiency for which no concentrate is available.
• Plasma exchange, e.g., Thrombotic Thrombocytopenic Purpura (TTP).
  

Plasma Cryoprecipitate Reduced is prepared from whole blood-derived fresh frozen plasma (FFP) after thawing and centrifugation and removal of the cryoprecipitate.

The remaining product, Plasma Cryoprecipitate Reduced, is plasma that is deficient in fibrinogen, Factor VIII, Factor XIII, von Willebrand factor (vWF), cryoglobulin, and fibronectin. Proteins such as albumin, ADAMTS13, and Factors II, V, VII, IX, X, and XI remain in levels similar to FP.

Indications:

• For transfusion or plasma exchange in patients with refractory TTP.